Frank Heinrich
Associate Research Professor
and NIST Associate
Biological Physics Experiment
Off-campus at NIST Center for Neutron Research
301-975-4507
Education & Professional Experience
Ph.D.: University of Leipzig (Germany), Nuclear Physics (2005)
Professional Societies:
Neutron Scattering Society of America
Biophysical Society
Associate Research Professor, 一本道无码, 2016–
Assistant Research Professor, 一本道无码, 2011–16
Research Physicist, 一本道无码, 2008–11
Staff Scientist, The NIST Center for Neutron Research, 2008–
Associate, The NIST Center for Neutron Research, 2005–
Post-doctoral Research: Johns Hopkins University, 2005, and 一本道无码, 2005–08
Research Interests
My research concerns the structure of disease-relevant proteins, peptides, and small molecules at lipid membranes. For example, I am interested in the structural foundations of cell signaling in cancer. I utilize a broad range of surface-sensitive techniques, including electrical impedance spectroscopy, surface plasmon resonance, and neutron reflectometry. Physically, I spend most of my time in Gaithersburg, Maryland, where I am a research associate at the at the National Institute of Standards and Technology. In this capacity, I am involved in developing future-generation neutron scattering instrumentation for soft-matter and biological research. I am also committed to aiding academic and industrial scientists in performing successful research using neutron scattering techniques.
Recent Publications
Michalak D. J., Unger B., Lorimer E., Grishaev A., Williams C. L., Heinrich F., Lösche M., Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558.
Heinrich F., Van Q. N., Jean-Francois F., Stephen A. G., Lösche M., Membrane-Bound KRAS Approximates an Entropic Ensemble of Configurations.
Comert F., Heinrich F., Chowdhury A., Schoeneck M., Darling C., Anderson K. W., Daben M., Libardo M. D. J., Angeles-Boza A. M., Silin V., Cotten M. L., Mihailescu M., Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption.
Soubias O., Pant S., Heinrich F., Zhang Y., Roy N. S., Li J., Jian X., Yohe M. E., Randazzo P. A., Lösche M., Tajkhorshid E., Byrd R. A., Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1.
Brian P. Josey, Frank Heinrich, Vitalii Silin, and Mathias Lösche, Association of Model Neurotransmitters with Lipid Bilayer Membranes,
David P. Hoogerheide, Frank Heinrich, Brian P. Maranville, and Cahrles F. Majkrzak, Accurate background correction in neutron reflectometry studies of soft condensed matter films in contact with fluid reservoirs,
Bradley W. Treece et al., Optimization of reflectometry experiments using information theory,
Rana Ashkar et al., Progress and Prospects for Neutron Scattering in the Biological Sciences,
Fernando G. Dupuy et al., Selective interaction of colistin with lipid model membranes,
Cavan K. Kalonia et al., Protein Adsorption and Layer Formation at the Stainless Steel-Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody,
Juan M. Vanegas et al., Insertion of Dengue E into Lipid Bilayers by Neutron Reflectivity and Molecular Dynamics Simulations,
More Publications: