一本道无码

A 一本道无码-led team has from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of implantable, cell-based bioelectronic devices that deliver patient-specific therapy and monitor disease status, for conditions like hypothyroidism and hyperthyroidism, in real time. This award is part of the听, which supports the advancement of implantable bioelectronic devices to improve patient management of chronic diseases.听

, professor of mechanical engineering at 一本道无码, will head the Biointegrated Implantable Systems for Cell-based Sensing and Therapy听(BIO-INSYNC)听project as the primary investigator. This effort is part of the ongoing Bioelectric Medicine Initiative at 一本道无码.听

In addition to Carnegie Mellon researchers, the multidisciplinary project team includes members from the University of Pittsburgh/UPMC, University of Florida, and University of California, Santa Cruz. Two companies, and , are also integral parts of the consortium.听

During the six-year project term, the team will develop and test two multipart, pacemaker-sized system platforms that will be implanted in a patient鈥檚 chest cavity through an outpatient procedure and听offer real-time, adjustable, low-cost therapy and disease monitoring for up to 12 months.听

Following a 鈥渓iving pharmacy鈥� concept, one of the systems will use human cells to produce and release the necessary dose of a hormone or other therapeutic molecules on demand. Utilizing a 鈥渓iving sentinel鈥� concept, the second system will use cells that measure critical biomarkers to monitor the patient鈥檚 disease status continuously in real time. Both will feature remote interfaces to communicate key information and measurements with the patient via smart devices or directly to their health care provider.听

While this technology can be used to treat various diseases and conditions, the collaborative team will specifically focus on its application to thyroid disorders, which impact an estimated 12% of Americans, including children and adults. BIO-INSYNC devices will provide a significant advantage to patients who will be able to continuously monitor key hormones and deliver the right therapeutic dose as needed, eliminating current management protocols like daily medications and regular blood testing. Notably,听the project will conduct a first-in-human clinical trial for patients facing thyroid conditions.

鈥淭he thyroid gland controls so many integral processes within the body, and thyroid hormone imbalances can lead to weight gain or loss, mental health issues, fertility problems, and even heart diseases,鈥� explained Ozdoganlar. 鈥淚t鈥檚 important also to note that thyroid disorders disproportionally impact vulnerable populations. Our bioelectronic system offers an innovative avenue for patients to self-manage their thyroid hormone levels at a fraction of the cost.听The aim is to improve patients鈥� quality of life by improving thyroid treatments while bridging听disparities in health care to attain equitable care for all.鈥�

This project is supported by the听. Additional researchers on the project include Carnegie Mellon faculty members Anne Robinson, Douglas Weber, Gary Fedder, James Schneider, Marc Dandin, Maysam Chamanzar, Phil Campbell, Philip LeDuc, and Rosalyn Abbott.