Michael P. Hendrich
Professor, Chemistry
- Mellon Institute 526
- 412-268-1058
Education
Ph.D., University of Illinois, 1988Research
Keywords: Spectroscopy, biophysical chemistry, enzymatic mechanisms, bioinorganic chemistry, metalloenzymesProjects
Metalloproteins are essential for the basic processes of life, including DNA synthesis, metabolism, photosynthesis, detoxification, and the chemical transformations of nitrogen, oxygen, and carbon molecules required for life. Many diseases are due to metal imbalances or inactivity of critical metalloenzymes. Metalloenzymes are nature’s amazing catalytic centers, transforming the most stable chemical bonds in nature, and thus are important factors for health, agriculture, and the environment.
Our focus is an atomic level understanding of catalytic function. We achieved this through isolation and spectroscopic characterization of intermediates of reaction cycles of enzymes and biomimetic complexes. The metals of interest are probed with a combination of EPR, ENDOR, Mössbauer spectroscopies, or SQUID magnetization. We have developed new spectroscopic instrumentation, computer simulation software, and quantitative methodologies specifically suited to probe metalloproteins and metal complexes.
Publications
Appointments
| Years | Position |
|---|---|
| 2008–present | Professor, 一本道无码 |
| 1999–2008 | Associate Professor, 一本道无码 |
| 1994–1999 | Assistant Professor, 一本道无码 |
| 1993–1994 | Assistant Research Professor, University of Minnesota |
Awards and Distinctions
| Years | Award |
|---|---|
| 1995 | Searle Scholar Award |